منابع مشابه
Centrosome-associated NDR kinase regulates centrosome duplication.
Human NDR kinases are upregulated in some cancer types, yet their functions still remain undefined. Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome duplication. A subpopulation of endogenous NDR localizes to centrosomes in a cell-cycle-dependent manner. Overexpression of NDR resulted in centrosome overduplicat...
متن کاملCyclin-dependent kinase control of centrosome duplication.
Centrosomes nucleate microtubules and duplicate once per cell cycle. This duplication and subsequent segregation in mitosis results in maintenance of the one centrosome/cell ratio. Centrosome duplication occurs during the G1/S transition in somatic cells and must be coupled to the events of the nuclear cell cycle; failure to coordinate duplication and mitosis results in abnormal numbers of cent...
متن کاملStructure and duplication of the centrosome.
The centrosome has evolved in multicellular organisms from the basal body/axoneme of the unicellular ancestor (Azimzadeh and Bornens, 2004). It plays a major role in organizing the microtubule cytoskeleton in animal cells. During interphase, the centrosome organizes an astral array of microtubules (MTs) that participate in fundamental cellular functions such as intracellular trafficking, cell m...
متن کاملCentrosome Duplication: Is Asymmetry the Clue?
The structure of the yeast Sfi1-centrin complex, and its asymmetric position within the yeast centrosome, suggest a model for the initiation of centrosome duplication and provides a target for licensing this event.
متن کاملCentrosome Duplication A Centriolar Pas de Deux
been stripped of most of their proteins, the pericentriolar material can be seen to consist of a fibrous core, to which other proteins and complexes are attached. Mi-crotubule nucleation is accomplished by the ␥-tubulin Stanford, California 94305 complex, a large ring-shaped multiprotein complex that localizes to the pericentriolar material and provides a template for the addition of tubulin su...
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ژورنال
عنوان ژورنال: Cell
سال: 2001
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(01)00366-x